From: u9264582@wumpus.cc.uow.edu.au (The RadioDog) Newsgroups: alt.drugs Subject: FWD : Analysis of current `extasy' Date: 1 Feb 1994 09:54:42 +1100 Message-ID: <2ik27i$4ro@wumpus.cc.uow.edu.au> Forwarded from the Ausrave mailing list ______________________________________________________________ An Analysis of "Hearts", a Tablet Illicitly Sold as "Ecstasy". ______________________________________________________________ Introduction: In recent months, observers have noticed an increase in the availablility of tablets sold illicitly as "ecstasy", supposedly methylenedioxy methamphetamine (MDMA), in Sydney. One form which has often been reported is known as "Hearts", and appears as a white tablet about 0.5cm in diameter, with a heart shaped emblem imprinted. A large number of these tablets were made available close to New Years Eve. Some experienced users claimed that the effect of the tablets was "smacky", i.e. they thought that it contained heroin in addition to MDMA. Up until a few months ago, in the Netherlands, the MDMA analogue N-ethyl methylenedioxyamphetamine (MDE, MDEA, Eve) was legal and freely available. With the banning of this substance, it would seem reasonable that the newly illicit stockpiles should have been distributed around the world. In recent years, quality MDMA has been rare in Sydney, and sales of adulterated or forged samples have correspondingly been rife. However, there have been persistant rumours of recent "ecstasy" supplies having their origin in the Netherlands, and indeed this has been used as a marketing point; people tending to believe that if it is imported, it is more likely to contain MDMA. All this suggests a possible link between recent "ecstasy" in supplies Sydney and Dutch MDE, so it is of great interest to analyse a sample of the drug. Experimental: 0.0398g of powdered "heart" tablet was suspended in 20ml H2O. The supernatant was placed in a separating funnel with 20ml CH2Cl2, and the residue re-extracted with ca.10ml H2O. To the combined extracts in the funnel were added 2ml 25% NH3. After shaking, the CH2Cl2 layer was separated, and a further three CH2Cl2 extracts of approximately equal volume were taken. These four extracts were combined, and evaporated under vacuum to yield 0.0121g of basic extract as a pale yellow oil. TLC on silica using butanol/acetic acid/ water (4:1:1) gave a single ninhydrin positive spot (violet, rf 0.55), indicating the probable presence of only one major component. The H1 NMR spectrum of the sample was taken, and found to correspond identically with an authentic sample of pure MDE having been worked up in the same manner. There was no evidence to suggest the presence of MDMA, or other amphetamines. Conclusion: The tablets known as "hearts" and sold as "ecstasy" have been found to contain at least 36% N-ethyl methylenedioxy amphetamine (MDE) (calculated as the hydrochloride salt). No other active substances were found. It is quite possible that the sample had its origin in the Netherlands. ___________________________________________________________________ Subjective differences between MDE and MDMA: While the effects of these two substances are sufficiently similar to make differentiation difficult, there are some significant subjective differences. MDE is somewhat less potent than MDMA, a typical dose being in the range 100-160mg (as opposed to 80-140mg). At large doses, MDE may resemble MDA (methylenedioxy amphetamine), although its psychedelic effects are less; it is a "stoning" intoxicant, and in particular can make walking or dancing difficult. Large doses of MDMA can have a similar effect, although it seems that somewhat more can be used without incurring the almost drunken intoxication. In smaller amounts, MDE greatly resembles MDMA, although the physical and tactile effects are generally perceived as being prevalent. The emotional opening and empathic effects for which MDMA is famous, although present, do not seem to be as pronounced. As a substance of abuse at raves, MDE has the possible advantage over MDMA that the user is less likely to embarass him/herself in public through inappropriate empathy. On the other hand, MDE is more likely to temporarily incapacitate the user at normal doses. Jeremy -- "Enjoy moderation in moderation" ----- THE d88888b .a888b d8888b d8P .a888b d8888b .a888b .a8888P d8P V8P d8P"d8P d8P V8P d8P d8P"V8P d8P V8P d8P"V8P d8P" d88888P" d88888P d8P d8P d8P d8P 88P d8P d8P d8P 88P d8P 88P" d8P V8b d8P d8P d8P.a8P d8P d8P.d8P d8P.a8P d8P.d8P d8P.d8P d8P "8B, d8P d8P d8888P" d8P V888P" d888P" V888P" V888P" u9264582@wumpus.cc.uow.edu.au - University of Wollongong, Australia