Newsgroups: alt.drugs From: andersom@spot.Colorado.EDU (Marc Anderson) Subject: Re: Info on methcathinone Message-ID: <1993Jul1.222440.8062@ucsu.Colorado.EDU> Date: Thu, 1 Jul 1993 22:24:40 GMT -----BEGIN PGP SIGNED MESSAGE----- [some text deleted -cak] medline only has two entries for 'methcathinone', both of which follow: - -marc andersom@spot.colorado.edu - ---------- cut here --------- AU - Glennon RA AU - Yousif M AU - Naiman N AU - Kalix P TI - Methcathinone: a new and potent amphetamine-like agent. AB - The purpose of the present investigation was to examine the effect of N-monomethylation of phenylisopropylamine derivatives on amphetamine- like activity. In tests of stimulus generalization using rats trained to discriminate 1.0 mg/kg of (+)-amphetamine from saline, the N- monomethyl derivatives of 1-(X-phenyl)-2-aminopropane, where X = 2,4- dimethoxy (2,4-DMA), 3,4-dimethoxy (3,4-DMA), 2,4,5-trimethoxy (2,4,5,-TMA), and 2-methoxy-4,5-methylenedioxy (MMDA-2), did not produce amphetamine-appropriate responding at the doses evaluated. However, the N-monomethyl derivative of cathinone (i.e., methcathinone), like cathinone, resulted in stimulus generalization. Further studies with this agent revealed that (a) in the amphetamine- trained animals, methcathinone (ED50 = 0.37 mg/kg) is more potent than racemic cathinone or racemic amphetamine (ED50 = 0.71 mg/kg in both cases), (b) methcathinone is capable of inducing release of radioactivity from [3H]dopamine-prelabeled tissue of rat caudate nucleus in a manner similar to that observed with cathinone, amphetamine, and methamphetamine, and (c) methcathinone is more potent than cathinone as a locomotor stimulant in mice as determined by their effect on spontaneous activity. The results of the present study provide evidence for a structural analogy between the prototypic psychostimulants amphetamine/methamphetamine and cathinone/methcathinone, and lend further support to the concept that amphetamine and cathinone correspond in their pharmacological effects. SO - Pharmacol Biochem Behav 1987 Mar;26(3):547-51 DP - 1987 Mar TA - Pharmacol Biochem Behav PG - 547-51 IP - 3 VI - 26 IS - 0091-3057 UI - 87204443 AU - Goldstone MS TI - 'Cat': methcathinone--a new drug of abuse [letter] AB - [No Abstract Available] SO - JAMA 1993 May 19;269(19):2508 DP - 1993 May 19 TA - JAMA PG - 2508 IP - 19 VI - 269 IS - 0098-7484 UI - 93253905 -----BEGIN PGP SIGNATURE----- Version: 2.2 iQBVAgUBLDNkHMUtKvnPICaNAQFfUgH/WRrFv/IMAFRBJTYH93igJSqY+SxTFXxw YpU005KcJ8DRDEU7Tbmx99rUkvLppDGseLP2Ac8JH8aW9N11L8jVSQ== =yz0/ -----END PGP SIGNATURE----- ============================================================================= From: ebrandt@jarthur.cs.hmc.edu (Eli Brandt) Newsgroups: alt.drugs Subject: Re: Homemade cat Date: 10 Jun 1994 03:51:55 GMT Message-ID: <2t8o0r$kjb@jaws.cs.hmc.edu> In article <135322Z09061994@anon.penet.fi>, Mud Phud wrote: >I found it to be much, much weaker than meth. The onset is slightly >slower (nasal route), there is no euphoria/rush, the high is like a >buzz with some of the heightened concentration and detail perception >ability, and the effects don't last as long as meth. I had no trouble >sleeping at night, unlike with a meth high. > >My question to the expert chemists in the group is why this might >be so. The cat refs on hmc seem to indicate that methcathinone and >methamphetamine should have equivalent or nearly equivalent effects. Maybe not. I have some notes comparing cathinone (the active principle of qat) with amphetamine. Rosecran et al. found that cathinone lacked DA agonist activity, and showed less disruption of behavior in animal studies. This is in Harris (ed.), _Problems of drug dependence_, NIDA, Monograph #27. I don't know whether this generalizes to methcathinone. Eli ebrandt@hmc.edu finger for PGP key. The above text is worth precisely its weight in gold.